5 products found
Newcells Biotech Limited Products
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Retina Models
Functional human cell-based models of the retina to study efficacy and safety of innovative ophthalmology therapies
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Retinal Organoids
Light responsive retinal organoids for accurate prediction of clinical outcomes. The retinal organoids recapitulate the complex structure of the human retina with laminar cell organisation mimicking embryonic development. They contain the outer photoreceptor segment of the retina that responds to light. Available analytical readouts: Immunofluorescence analyses, mRNA quantification by RT-qPCR, Transcriptomic analysis by single-cell RNA sequencing, ...
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Retinal Pigment Epithelium (RPE)
A functional monolayer in vitro model of retinal pigment epithelial cells generated from human iPSCs for accurate prediction of clinical outcomes. The retinal pigment epithelial (RPE) cell model is composed of a monolayer of RPE cells cultured in 24-well Transwell® plates. RPE characterisation includes: morphology assessment, pigmentation, RPE-specific expression at the protein level (BEST1, TYRP1), the analysis of phagocytosis of ...
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Models of the Nephron
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Model aProximate - Proximal Tubule
Kidney proximal tubule cell model for safety/efficacy and transporter studies. aProximate™ is one of the most advanced, near physiological, in vitro, kidney proximal tubule cell (PTC) models. aProximate™ PTCs are derived from fresh human kidney tissue and grown on Transwells® where they remain as a functional polarised cell layer that forms tight junctions. In contrast to other primary and immortalised kidney proximal ...
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Glomerulus
Podocyte model for assessing glomerular toxicity. Newcells now offers the first fully differentiated, primary podocyte model derived from fresh kidney tissue for the in vitro assessment of drug-induced glomerular toxicity. The effect of a drug on the glomerular filtration barrier and podocyte glomerular permeability can now be easily evaluated in vitro. Podocyte injury and proteinuria can be modelled in ...
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Lung Airway Models
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Human Lung Fibroblasts
Human lung fibroblast model to test the efficacy of anti-fibrotic agents in vitro. Newcells human primary lung fibroblast model is the basis of our FMT assay to evaluate anti-fibrotic therapies in vitro at high throughput. The assay replicates extracellular matrix deposition (ECM) observed in vivo when lung fibroblast injury leads to activation and proliferation. Following injury, pulmonary fibroblasts ...