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Retinal Pigment Epithelium (RPE)
A functional monolayer in vitro model of retinal pigment epithelial cells generated from human iPSCs for accurate prediction of clinical outcomes. The retinal pigment epithelial (RPE) cell model is composed of a monolayer of RPE cells cultured in 24-well Transwell® plates. RPE characterisation includes: morphology assessment, pigmentation, RPE-specific expression at the protein level (BEST1, TYRP1), the analysis of phagocytosis of photoreceptor outer segments, trans-epithelial resistance (TEER), polarity of apical Pigment Epithelium-Derived Factors (PEDF) and basal vascular endothelial growth factor (VEGF) secretion.
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- Immunofluorescence
- mRNA quantification by RT-qPCR
- Transcriptomics by single-cell RNA sequencing
- Growth factor (VEGF, PEDF) secretion
- Flow cytometry
- Electron microscopy
Model formats
- Frozen human iPSC-derived RPE cells (coming soon)
- RPE cells cultured in 24-well Transwell® plates
Cell Types
- Retinal pigment epithelial (RPE) cells
Species
- Human (healthy donor)
- Human (gene-edited)
Accelerate your lead compound selection by understanding their mode of action in functional retinal tissue
- Mature and functional RPE model
- Well-characterised and reproducible
- Rapid evaluation of gene therapy vectors