Boston Pharmaceuticals
Boston - Model BOS-371 - Potent Monoclonal Antibody
BOS-371 is a highly potent monoclonal antibody targeting the Interleukin-1 Receptor Accessory Protein (IL1RAP), a prevalent tumor associated antigen driving tumor growth and immunosuppression. BOS-371 has also been Fc-engineered to enhance effector function.
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- IL1RAP mediates IL-1, IL-33, and IL-36 signaling in tumor and immune cells. Targeting IL1RAP has demonstrated anti-tumor activity in animal models of both hematologic and solid tumor malignancies while enhancement of effector function has been shown to increase the tumoricidal activity of multiple different antibody therapeutics.
- BOS-371 has the potential to be active in AML and other tumors expressing IL1RAP.