Alfa Chemistry - Lead Optimization for Drug Discovery
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds or biologics in lead optimization process. Alfa Chemistry determines accurately the basic characteristics of leads to understand the need for lead optimization. We fully consider basic attributes: potency, bioavailability, duration, safety, and pharmaceutical acceptability to ensure a program's ultimate success.
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