Immune Tolerance Articles & Analysis
10 articles found
The primary focus is on harnessing this technology for modifying primary T cells, a type of white blood cell crucial for the immune response. This approach has opened new avenues for immunotherapy, providing hope for treating conditions like cancer, autoimmune disorders, and genetic diseases. ...
Especially when the host's own tissues express target antigens, the phenomenon of immune tolerance may hinder the stimulation of effective immune responses, thereby increasing research difficulty. ...
Their main function is to suppress the activation of other effector T cells, induce immune tolerance and exert immunomodulatory effects. Treg cells secrete IL-10 and transforming growth factor-ß (TGF-ß), which together induce Treg cells to differentiate continuously or inhibit the activation and proliferation of effector immune cells ...
Ly6c+ cells serve as targets for treating IBD, and the immune-suppressive cytokine IL-10 has been reported to inhibit IBD. To induce long-term IL-10 production, IL-10 mRNA-loaded LNP was first prepared, followed by incubation with anchored secondary scFv enabling targeting (ASSET) micelles at 4°C for 48 hours and subsequent incubation with anti-Ly6c monoclonal antibody for 30 ...
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and ...
In addition, it aids in the development of regulatory T cells (Tregs), thereby producing peripheral T cell immune tolerance, as well as regulating the proliferation and differentiation of activated T cells. ...
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy metabolism, glucose tolerance, immune system maturation and function in humans1,2,3,4. Although A. muciniphila is correlated with metabolic diseases and its beneficial causal effects were reported on host metabolism5,6,7,8, the molecular mechanisms involved have not been ...
Organs influenced by immune dynamics in the gut.(1) A Gut Check for Tumor Overgrowth Enzymes Work Better in a Cage Are IPS Cells Safe for Therapeutic Use? ...
Experimental results reveal pronounced systemic immunity and serum antibodies in the group vaccinated by injection. The orally vaccinated group demonstrated more expressed local immunity and mucous antibodies than control group. However, in this group, some tolerance induction occurred in the lungs during the first two vaccinations. We thus ...
The results indicate that Immunoxel is safe and exerts beneficial effect in AIDS patients.Keywords: cachexia, hepatotoxicity, immune tolerance, CD4 cell counts, immunotherapy, phytotherapy, transaminase, antiretroviral therapy, HIV infection, immunomodulating agents, ...