Immune Tolerance Articles & Analysis
17 news found
Evaluation of a beta cell replacement therapy combined product that avoids the need for immunosuppression via localized induction of immune ...
“As we continue to advance clinical development of our pipeline, we believe our addition to the Russell indexes will broaden awareness of the biological advantages of placental-derived cell therapies, including both greater proliferative performance and natural immune tolerance. We remain committed to leading the next evolution of cellular therapies for the ...
Data presentations include review of the VE303 Phase 2 CONSORTIUM study, in which VE303 was well tolerated and highly active at preventing Clostridioides difficile infection recurrence in subjects at high risk of recurrence Further CONSORTIUM study analysis shows that the VE303 high dose led to more robust colonization, which in turn correlated with prevention of recurrence ...
(NASDAQ: HOOK, ‘HOOKIPA’), a company developing a new class of immunotherapeutics based on its proprietary arenavirus platform, today announced positive preclinical data demonstrating potent T cell responses, potential novel combination use beyond PD-1 inhibitors, and the ability to break immune tolerance to various self-antigens for targeting ...
LILRB4 inhibits antigen-presenting cell function, resulting in immune tolerance. LILRB4 is also expressed on certain hematologic cancer cells. ...
(Prellis), a Bay Area biotherapeutics company, announced today that it has entered into a collaboration and license option agreement with Sanofi S.A. focused on the discovery of antibodies with Prellis’ first-in-class external human immune system (EXIS). The collaboration leverages Prellis’ ability to engineer fully-human lymph node organoids (LNOs™) and ...
Our DNA medicines are delivered using our proprietary smart device to produce a robust and tolerable immune response against targeted pathogens and cancers. INOVIO is evaluating candidate VGX-3100 in two Phase 3 trials for precancerous high-grade cervical dysplasia caused by HPV-16 and/or HPV-18. ...
Our DNA medicines are delivered using our proprietary smart device to produce a robust and tolerable immune response against targeted pathogens and cancers. INOVIO is evaluating candidate VGX-3100 in two Phase 3 trials for precancerous high-grade cervical dysplasia caused by HPV-16 and/or HPV-18. ...
Researchers who worked on a joint project among Columbia University Medical Center, Albert Einstein College of Medicine, and St John's University sought to elucidate the mechanisms by which maternal consumption of a high-fat diet leads to a dysregulated immune response and, subsequently, spontaneous preterm birth. " We performed 16S ribosomal RNA sequencing of DNA extracted and ...
INOVIO is working rapidly to assess the immune responses against the Omicron variant; data are expected in the coming weeks. ...
INO-4201 is composed of a precisely designed DNA plasmid that is injected intradermally followed by electroporation using a proprietary smart device, which delivers the DNA plasmid directly into cells in the body and is intended to produce a well-tolerated immune response. As one of the only nucleic acid-based vaccine candidates INO-4201 is stable at room ...
The antigen is processed naturally in the cell and triggers the desired T cell and antibody-mediated immune responses. Administration with the CELLECTRA® device is designed to ensure that the vaccine is efficiently delivered directly into the body's cells, where it can go to work to drive an immune response. ...
” Intrommune’s lead product in development, INT301, utilizes the oral mucosal immunotherapy platform (OMIT) to decrease allergic immune response in patients through daily tooth brushing. The product delivers allergenic proteins to areas of the oral cavity to naturally trigger an immune system response towards tolerance of the ...
About VE202 VE202 is a first-in-class, orally administered, investigational LBP consortium consisting of 16 bacterial strains of the Clostridia class, which were rationally selected to induce immune tolerance in the gut, reverse the gut microbiota abnormalities that are common in patients with IBD, and strengthen the epithelial barrier. ...
The candidate generated strong immune responses in animal models and was approved for combined phase 1 and 2 clinical trials by the South Korean Ministry of Food and Drug Safety in January. The first phase will include 50 healthy Korean adults and tests for safety, tolerance and immune response. The second phase will include 230 adults and tests ...
Siolta leverages their deep knowledge of the developing infant gut microbiome and its role in promoting immune tolerance to develop targeted microbial therapeutics and companion diagnostics for the prevention and treatment of inflammatory diseases. ...
Siolta Therapeutics, a clinical-stage biotech company, researches specific microbes that promote healthy gut microbiome development in infants to prevent immune dysfunction in childhood. The company has built a human-centric development platform that delivers patient screening for high-risk candidates, targeted microbial therapeutics, and biomarker discovery for ...