Renal Injury Articles & Analysis
19 articles found
Hello, and welcome back to the Colorful Researcher’s blog. In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. In his post, Peter explained how small instruments like BUCHI’s Glass Oven G-300 are great for working with small ...
ByBUCHI
The Role of Podocytes in Kidney Disease Recent research has highlighted the importance of podocytes in various renal pathologies. Conditions such as diabetic nephropathy, focal segmental glomerulosclerosis, and nephrotic syndrome are characterized by podocyte injury or loss. ...
The human brain has long been regarded as one of the most enigmatic subjects in both medicine and science, captivating interest since ancient times. Its intricate architecture and advanced functionalities continue to inspire awe. However, it is through the lens of contemporary medical technology that we can begin to uncover the secrets within the brain, revealing the intricate structures nestled ...
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
These patients did not have HIV/AIDS, end-stage renal disease, kidney transplantation or other organ transplantation. ...
The spinal cord is to relay messages between the brain and the rest of the boy. When spinal cord injury happens the body may lose some essential functions if the nerves can’t communicate with the brain. Inadequate bladder management of spinal cord injury (SCI) results in medical complications, psychological stress and even mortality. ...
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. Tetrahydrocurcumin can effectively inhibit tyrosinase, inhibit the generation of Oxygen Free Radicals and scavenge the formed free radicals. It has obvious antioxidant ...
Representing the expression, post-translational modification, and protein-protein interaction for certain cells, tissues, or organs, proteomics has become an increasingly important means to understand the molecular mechanism and signal transduction of human disease and cancer. Protein levels in the body are in a steady state of equilibrium. Accumulation of proteins usually leads to qualitative ...
Mice kidney samples are used to study renal biology covering topics such as acute kidney injury to chronic kidney disease, both of which are extremely useful for better understanding renal failure in humans. ...
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects. MCP- treated mice demonstrated increased renal ...
In a rat renal I/R injury model, Gal-3 levels, renal function, and histopathology were evaluated in rats pretreated with P-MCP for one week (n = 16) compared to controls (n = 16). ...
Improve sepsis testing accuracy. Enhance patient safety. These are the driving forces behind Magnolia Medical Technology’s Mission to ZERO. Mission to ZERO™ is a nationwide plan to create greater awareness of patient safety and antibiotic-associated risks caused by false-positive diagnostic test results for sepsis. The goal is to initiate change by improving national blood culture ...
Abstract Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3's role and its potential utility as a therapeutic target in S-AKI. Methods: In 57 patients admitted to the intensive care unit (ICU) with ...
Clinical Case Study: Grady Health, Atlanta, GA. A Case study, utilizing a novel remote monitoring tablet, directly connected to the Accuryn Monitoring System. Background: There are an estimated 300,000 deaths from acute kidney injury (AKI) annually in the U.S.1 A mountain of growing clinical literature has shown that hourly urine output (UO) monitoring may lead to earlier recognition of AKI ...
Annotations Acute kidney injury (AKI) is recognized as a potential risk factor for future cardiovascular events, especially heart failure. Up to 60% of patients with severe AKI who are admitted to an intensive care unit (ICU) die; the long-term risk of death associated with AKI is also increased. Preclinical models and biomarkers have identified several likely pathways, apparently involving ...
Google DeepMind recently published a paper in Nature that shared how their predictive algorithm can detect Acute Kidney Injury (AKI) up to 48 hours in advance. Acute Kidney Injury is the biggest problem you have never heard of. In the US, 1 in 5 hospitalized adults gets Acute Kidney Injury, resulting in a 5x risk of death. It takes the lives ...
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...
Annotations Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve. Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the lowest third. Elevated preoperative Gal-3 levels significantly ...
Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased perivascular cellularity and area with ...