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Aflocox is a multi-component management tool which capitalizes on the synergistic effect of selected plant bioactives. Saponins and terpenoids provide direct antiparasitic action against Eimeria, while additional components support immune responses and gut integrity. Research has confirmed anti-inflammatory, immunomodulatory and anti-oxidant impacts. ...
ByInnovad
Adeno-associated viruses (AAVs) are derived from defective parvoviruses, which depend on essential helper functions provided by other viruses, such as adenovirus and herpes virus, for efficient viral replication and propagation. AAV has no etiologic association with any known diseases and has been successfully used to establish efficient and long-term gene expression in vivo in a variety of ...
Amaferm® is a precision prebiotic designed to boost animal resilience to challenges. It is research-prove to improve gut integrity and immune ...
Clone CF-1D12 recognizes human CD52, a 21-28 kDa glycoprotein whose C-terminus is glycophosphatidylinositol (GPI) anchored within the membrane. It is also known as Cambridge pathology antigen 1 (CAMPATH-1). Binding of CF-1D12 with CD52 induces a potent complement-mediated cytolytic immune response of matured lymphocytes. It is widely expressed on the surface of thymocytes and mature lymphocytes, ...
MHC class I related protein (MR1) molecules are non-polymorphic, non-classical major histocompatibility complex (MHC) molecules that are highly conserved across many mammalian species. The ligand binding groove of the MR1 molecule has been shown to bind small molecules derived from microbial riboflavin biosynthetic pathways and present these to mucosal associated invariant T cells (MAIT cells). ...
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen & Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and ...
T cells play essential roles in adaptive immune responses to viruses, bacteria, parasites, tumors, transplanted tissues, allergens and even to self antigens. Applications for using pMHC tetramers are rapidly expanding and include exciting new possibilities for ex vivo cell expansion and for ...
MHC Tetramers have emerged as an important tool for characterization of the specificity and phenotype of T cell immune response, useful in a large variety of disease and vaccine ...
Proper vaccine storage and handling are important factors in preventing and eradicating many common vaccinepreventable diseases. Yet, each year, storage and handling errors result in revaccination of many patients and signifcant fnancial loss due to wasted vaccines. Failure to store and handle vaccines properly can reduce vaccine potency, resulting in inadequate immune responses in patients and ...
T cells play critical effector and regulatory roles in adaptive immune responses to bacteria. And MHC Tetramers have been proved to be very effective in identifying antigen-specific T cells by flow cytometry, even those present at low frequencies in fresh populations of lymphocytes sampled directly ex ...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its ...
Effectively introduced DNA vaccines represent a powerful and safe means for stimulating an immune response that recognizes and eliminates target molecules in the body. However, traditional DNA vaccine delivery systems such as gene gun delivery electroporation suffer from poor efficiency. The BTX AgilePulse In Vivo System provides an intra-dermal/muscular electro-poration solution to produce ...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its ...
TCR profiling holds great potential not only for understanding the mechanisms of development of the normal immune response, but also in providing insights into disease mechanisms and development of new therapeutics and treatment modalities in infectious diseases, autoimmunity and in immuno-oncology. However, identification of all potential clonotypes in a diverse repertoire of TCRs requires ...
The SARS-CoV-2 IgM ELISA kit is an in vitro diagnostic test for the qualitative detection of IgM antibodies to SARS-CoV-2 in human serum. The kit is intended for use as an aid in identifying individuals with an adaptive immune response to SARSCoV- 2, indicating recent or prior ...
OncoPeptTUME — A novel in-silico approach to model the tumor microenvironment and predict treatment efficacy and long-term survival benefits for immunotherapy applications. Cancer immunotherapy is now established as a major therapeutic modality. Cancer immunotherapy drugs elicit their anti-tumor immune response in a subset of the treated patients by activating CD8 T-cells and provide ...
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the infectivity of M-tropic HIV-1 strains. Proteolytic removal of the two ...
To date, the classification of cancers has been based solely on the phenotypic and genotypic characteristics of tumor cells. A new paradigm, scientifically well established and recommended by WHO guidelines, relies on the introduction of the immune response as a new prognostic parameter to predict and refine the clinical outcomes of cancer patients. Maximize patient survival rates with an ...
ByVeracyte
Immunogenicity assays play a vital role in evaluating the safety and efficacy of vaccines by measuring the immune response induced in vaccinated individuals, and serve as crucial tools in vaccine development, clinical trials, licensure, and post-marketing surveillance. Various methods are employed in vaccine immunogenicity assays, ranging from traditional techniques like LBAs to advanced ...
The COVID-19 Vaccine IgG Rapid Test is a lateral flow immunoassay intended for the qualitative detection of antibodies binding to the Receptor Binding Domain (RBD) of the spike protein of the SARS-CoV-2 virus or COVID-19 vaccine in human serum, plasma or whole blood. The kit is intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2, indicating recent ...