Hematology Articles
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What are Radionuclide Drug Conjugates (RDCs)?
Coupling drugs combine the precise targeting and potent killing properties, has become a widely recognized form of medication in recent years. Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. According to the application of RDCs, they can be divided into two main categories: diagnostic RDCs ...
By BOC Sciences
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Drug-Loaded Liposomes: Tiny Spheres with Big Potential
Imagine tiny bubbles, smaller than a red blood cell, carrying powerful medicines directly to diseased cells. This isn't science fiction, it's the cutting edge of drug delivery with drug-loaded liposomes. What are liposomes? Liposomes are microscopic spheres made from phospholipids, the same fatty molecules that make up cell membranes. These phospholipids naturally arrange themselves in ...
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Shining a Light on Drug Delivery: The Rise of Fluorescent Liposomes
Imagine tiny spheres, smaller than a red blood cell, glowing as they navigate the labyrinthine corridors of the human body. These aren't fireflies, they're fluorescent liposomes, a cutting-edge tool in the world of drug delivery and biomedical research. What are liposomes? Liposomes are microscopic bubbles made from phospholipids, the same fatty molecules that make up cell membranes. These ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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Cytokines in CAR-T Cell Therapy
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for the treatment of tumors. Compared with ...
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Inflammation, Immunity and Cancer
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune ...
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The C-Myc Oncogene Is Associated with Aging, New Study Found
The Myc gene is one of the most important drivers of cancer in mice and humans. Myc also plays a newly discovered key role in aging, according to a new study in Cell Reports by researchers at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine. The study, led by Edward V. Prochownik, MD, UPMC Children's Hematology/Oncology Division and Paul C. Gaffney ...
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ADC Cleavable Linker : Classification and Mechanism of Action
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and ...
By BOC Sciences
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Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli ...
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Types and Function of Oligosaccharides
Types of Oligosaccharides Disaccharides These are the sugars having two monomeric units, and thus it is called di_saccharide. Some examples are maltose, sucrose, and lactose. Maltose is the action of an enzyme and it gives glucose +glucose; Sucrose (or cane sugar) in the action of invertase produces fructose + glucose, and Lactose(milk sugar) in the action of enzyme lactase produces galactose + ...
By BOC Sciences
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Huateng Pharma Supplies Some Intermediates of CDK4/6 Inhibitors for Treatment of Advanced Breast Cancer
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. In 2018, it is estimated that 627,000 women died from breast cancer – that is approximately 15% of all cancer deaths among women. While breast cancer rates are higher among women in more developed regions, rates are ...
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Autoimmune Diseases Targets
Thymic Stromal Lymphopoietin (TSLP) is a multifunctional cytokine that acts on various cell types, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils, and innate lymphoid cells, affecting their maturation, survival, and recruitment. It is well-known for its role in promoting type 2 immune responses, such as allergic diseases. In 2021, a monoclonal antibody targeting ...
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Unlocking nature’s secrets? How Nuritas harnesses AI to uncover hidden health-boosting ingredients
Biotech company Nuritas speeds up ingredient discovery in nutrition through AI, using techniques from the pharmaceutical industry where innovation and investment rates are much higher. Through its bioactive peptide finder, Magnifier NπΦ, the company can boast a clinical trial success rate of 80%. Development of an ingredient goes through three phases, from discovery to preclinical biology ...
By Nuritas Ltd.
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Detecting Fusion Transcripts by RNA Sequencing in Screening Tumors
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors. For example, in chronic granulocytic leukemia, ...
By CD Genomics
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Unravelling the Hypertension Puzzle
In this busy and crowded world, no one has the time or energy to look after themselves; our lack of effort and diminished sense of responsibility towards our health has led to stress, tension, and various health issues becoming an inseparable part of our lifestyle. One of the most popularly spread health issues is hypertension. According to estimates by The World Health ...
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Clinical and operational benefits of EchoGo® Heart Failure for HFpEF detection
Preliminary results of a large-scale study demonstrating the clinical benefits of EchoGo® Heart Failure were shared at the American College of Cardiology (ACC 2023) conference last month. Using only an apical four-chamber ultrasound view, this new AI-enabled platform can identify heart failure with preserved ejection fraction (HFpEF) and has been shown to minimize the indeterminate ...
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Study on Partial Glycoprotein of Feline Herpesvirus Type 1
Feline herpesvirus type 1 (FHV-1) can cause acute and highly contagious infectious diseases in cats, namely feline infectious rhinotracheitis. In 1958, FHV-1 was isolated and identified for the first time from kittens suffering from respiratory diseases in the United States by Crandell et al. Clinical manifestations include keratoconjunctivitis, upper respiratory tract infection and miscarriage, ...
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Blood Storage and Preservation
How Is Blood Stored and Preserved? Blood storage is an important process in the blood banking industry as it helps maintain the quality of blood and its medical effectiveness. Blood can be stored in a few different ways, but the most common method is refrigeration.Blood banks depend on donors to provide blood and blood components. When blood is collected from a donor, it must be processed to ...
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Diagnosing heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine, overtaking heart failure with reduced ejection fraction (HFrEF) and becoming the most common form of heart failure, with a prevalence that is increasing by 1% annually.[1] Despite this, there remains no gold standard in diagnosing HFpEF. Diagnosing ...
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Breaking Barriers – Past and Current: Celebrating the Legacy of Dr. Clarice Reid, Pioneer in Sickle Cell Research, Biomark Diagnostics
Dr. Clarice Reid was a trailblazer in the field of sickle cell disease, dedicating her life and career to improving the lives of those affected by this debilitating genetic blood disorder. As a pioneering black woman in the field of medicine and science, Dr. Reid’s work has made a significant impact on our understanding of this condition and has paved the way for the development of ...
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