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For the current population of adults 40 or older, the suffering from bone degeneration is approaching 90% (Nag and Banerjee, 2012), predominantly with site-specific damage such as hip and shoulder ...
ByZygo Corporation - AMETEK, Inc based in Middlefield, CONNECTICUT (USA)
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Medical and life science manufacturers are pressured to drive continual innovation and advancement with short time-to-market goals. These industries also demand strict process controls and quality standards. Success often rests on the ability to choose the right partner — one that can be trusted to have the right knowledge and experience to help them meet these stringent ...
ByZygo Corporation - AMETEK, Inc based in Middlefield, CONNECTICUT (USA)
Embracing the use of HBOT to favor aesthetic objectives is a relatively new approach to an ever-growing complementary treatment, oxygen ...
ByOXYHELP INDUSTRY based in Bucuresti, ROMANIA
PLGA nanospheres have already been successfully used in vitro and in clinical trials. Results show that drugs encapsulated in PLGA nanoparticles have superior accumulation in the tumor environment, reduced tumor size and enhanced inhibition of cell proliferation. This is thanks to increased cell penetration and reduced toxicity of encapsulated compounds. Because of the higher accumulation in tumoral areas PLGA nanoparticles are also useful for cancer diagnosis and imaging which has a key role in clinical oncology ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Downregulating the immune response is necessary for the treatment of autoimmune diseases. In this aspect, the APO2L/TRAIL ligand is a key intermediate in immune cascades and is secreted in exosomes in natural conditions. Its alteration has been associated with rheumatoid arthritis. The administration of synthetic exosomes decorated with APO2L/TRAIL has been shown to be effective in reducing the hyperplasia and overall inflammation in this ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Exosomes are natural genetic material carriers, including mRNA, miRNA and siRNA. This material cannot be used in its naked form since it is very sensitive to degradation by ribonucleases, and it cannot enter the cells freely. Encapsulation in synthetic exosomes is an advantageous approach: it preserves the RNA and allows a path for cell ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Inside the hyperbaric chamber, a user will absorb oxygen close to four times the normal breathing ...
ByOXYHELP INDUSTRY based in Bucuresti, ROMANIA
The development of highly cytotoxic drugs is needed for the success of the treatment in tumor cells. Paradoxically, the high toxicity limits its efficacy and application in vivo, causing damage to non-target organs and severe secondary effects. The use of directed liposomes has allowed the advance of many cancer drugs to preclinical and clinical trials, reducing side effects, and increasing their therapeutic index at the same time. More than 15 cancer liposomed drugs are currently clinically ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Antigens can be carried by liposomes, either lipids, proteins, DNA or RNA. They can also be combined with bacteria or virus components to form archaeosomes or virosomes, respectively. These vaccines have been proved to be effective in inducing immune responses and providing a sustained exposure to the antigen. More than 30 clinical trials are currently using liposomes for vaccine delivery including HIV and several types of ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The increase or decrease of a natural immune response to obtain a therapeutic result is the basis of immunotherapy. It holds great promise for the treatment of autoimmune diseases, cancer, and the prevention of transplant ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Tissue regeneration is aimed at the reconstruction of a tissue or organ that requires that cells coordinate timely and spatially to proliferate and differentiate. This comprises complex cell signaling to regulate cellular activity. The delivery of growth and differentiation factors face a rapid in vivo clearance that will benefit greatly from encapsulation in liposomes. Apart from protection, liposomes target the specific cell populations to develop in a scaffold and allow a spatio-temporal controlled delivery. ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Drug delivery in the retina is normally performed through intravitreal injection but it is only suitable for compounds fitting a list of criteria like long half-lives. Decoration of engineered exosomes derived from retinal cells with hyaluronan binding peptides is a very effective alternative to intravitreal injection. Hyaluronan can be found in high concentrations in the vitreous of the eye, and thus, this strategy enhances the penetration and uptake from retina ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Automatically depackage and remove pills and tablets in large volumes through the Dominator depackaging machine. Fully packaged pharmaceuticals and cosmetics products can be put straight into the de-packaging machine separating the medicines from the plastic and cardboard. Deblister tablets, remove pills from plastic ...
ByRowan Food and Biomass Engineering Ltd based in Cheltenham, UNITED KINGDOM
A number of methods have been reported for the measurement of calcium in biological materials by flame photometry or titration. This method employs trichloroacetic acid (TCA) to precipitate the proteins and has been found to be adequate to extract all of the calcium from tissue samples. Sodium, potassium and phosphate caused no significant interference and calcium concentration in the range of 0 to 2 µg/ml is readily determined. ...
ByBWB Technologies Ltd. based in Newbury, UNITED KINGDOM
Hyperbaric Oxygen Therapy (HBOT) for professional sports has become one of the most effective methods for athlete ...
ByOXYHELP INDUSTRY based in Bucuresti, ROMANIA
The use of genetic material as therapeutic compounds to adjust dysfunctional cell behaviors is a revolutionary approach that has gained more attention in recent years in the medical field. Up or downregulation of genetic expression leads to an increased or decreased production of proteins respectively. The main challenge that gene therapy faces with naked genetic material is the low transfection rates and thus, therapeutic efficacy. Their physical properties as big sizes and polarity, difficult the permeation ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The defense mechanisms observed in the eye (epithelium, tear flow and blinking reflex) hamper the drug penetration into deeper layers of the eye. The use of modified liposomes with mucoadhesive polymers and a specific lipid formula helped in overcoming these surface obstacles and reaching target areas as the conjunctival ...
ByNanovex Biotechnologies based in Llanera, SPAIN
ByAMETEK Process Instruments based in Pittsburgh, PENNSYLVANIA (USA)
Like other nanocarriers, synthetic exosomes can be used to treat different types of cancer successfully, by encapsulating the desired anti-tumoral drug or RNA and enzymes. Several studies have used engineered exosomes from dendritic or macrophage cells to release chemotherapeutic compounds as doxorubicin, paclitaxel miRNA or siRNA to induce antitumoral activity. Rodent mammary carcinoma, mice lung cancer, glioma and pancreatic cancer are just some targeted diseases in preclinical testing using exosome delivery ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The trespassing of the blood brain barrier is a challenge for the treatment of central nervous diseases such as Alzheimer, Parkinson, stroke, or cancer (glioma). The endothelium shows tight junctions and specialized transporters which limits the bioavailability of drugs in the central nervous ...
ByNanovex Biotechnologies based in Llanera, SPAIN