bone density Articles
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Targeted disruption of the wnt regulator kremen induces limb defects and high bone density
Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/β-catenin signaling. The physiological relevance of Kremen proteins in mammals as Wnt modulators is unresolved. We generated and characterized Krm mutant mice and found that double mutants show enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ...
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Differential effects of abaloparatide and teriparatide on hip cortical volumetric BMD by DXA-based 3D modeling
Abstract In postmenopausal osteoporotic women in ACTIVE, abaloparatide reduced fracture risk and increased areal bone mineral density (BMD) more than teriparatide at the hip and wrist. DXA-based 3D modeling showed significantly greater increases in hip cortical volumetric BMD with abaloparatide versus teriparatide. This may explain differences reported in aBMD by DXA. Introduction: In ...
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Bone Analysis Using Trabecular Bone Score and Dual-Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling in Postmenopausal Women With Primary Hyperparathyroidism
Abstract Objective: Predominance of bone loss in cortical sites with relative preservation of trabecular bone, even in postmenopausal women, has been described in primary hyperparathyroidism (PHPT). The aim of this study was to evaluate bone microarchitectural differences using dual-energy x-ray absorptiometry (DXA), trabecular bone score (TBS), and DXA-based 3-dimensional (3D) modeling ...
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Impact of feeding flaxseed oil on delaying the development of osteoporosis in ovariectomised diabetic rats
This work is aimed to study the effect of diabetes on bone health and to evaluate the impact of feeding flaxseed oil on delaying osteoporosis. About 70 female albino rats were included; 30 were ovariectomised (ovx). Experimental diabetes was induced. Rats were classified in groups as control, sham, diabetic, diabetic received flaxseed oil in the diet, ovx, ovx-diabetic and ovx-diabetic received ...
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Advantages of using Spine 3D(CT-based) Navigation in complex Spine Surgeries
To confidently perform a spinal fusion and screw fixation with excellence surgical navigation is consistently used as a powerful tool. Surgical Navigation provides real-time guidance and precise measurements for accurately placing the pedicle screws to help stabilize the spine. A preoperative CT scan gives a detailed visualization of the structure decreasing the potential for implant-related ...
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Regional changes in indices of bone strength of upper and lower limbs in response to high-intensity impact loading or high-intensity resistance training
Abstract It is well known that the bone response to physical activity is highly dependent on the nature of the loads imposed. Despite this, few direct comparisons of the effect of impact-style loading and resistance training on bone have been made. We therefore aimed to compare the effects of 10-month, twice-weekly, high-impact loading and 10-month, twice-weekly, high-intensity resistance ...
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Peptides for Osteoporosis Research
Introduction to OsteoporosisOsteoporosis is a systemic multi-causal skeletal disease that is prone to fractures due to changes in systemic bone mass and microstructure of bone tissue, resulting in increased bone fragility. Osteoporosis is a type of disease that is difficult to cure. According to the etiology, it can be divided into primary osteoporosis, secondary osteoporosis and idiopathic ...
By BOC Sciences
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Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFTMOR-M semi-randomised controlled trial
Abstract Introduction: Few data exist on the effects of bone-targeted exercise on geometric and biomechanical indices of bone strength in men. The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR-M) trial was designed to compare the efficacy and safety of two novel, supervised, twice-weekly, high-intensity exercise programs in middle-aged and older ...
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Imaging Complex Cell Morphology: Mesenchymal Stem Cells (MSCs)
MSCs exhibit specific morphology, which makes them unique compared to other cell types typically used in CLD. While forming spindle-shaped, elongated, and transparent cell projections, the MSCs can pose a significant challenge when it comes to imaging and subsequent image analysis. Many imaging systems on the market are simply not fit for precise detection of these unusual cell types. ...
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Dynamic Navigation for Precision Crestal Approach Osteotomy Near the Maxillary Sinus Floor - Case study
INTRODUCTION The goal of the implant surgeon is to place the implant in the ideal position, to support the prosthesis for the best long term prognosis, while managing important anatomical landmarks. With the aid of Cone Beam CT scans the implant surgeon is able to evaluate, in three dimension, the ridge, important anatomy, as well as pre-plan implant placement in the most ideal position. ...
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Proximal Femur Responses to Sequential Therapy With Abaloparatide Followed by Alendronate in Postmenopausal Women With Osteoporosis by 3D Modeling of Hip Dual-Energy X-Ray Absorptiometry (DXA)
ABSTRACT Previous subgroup analyses from the ACTIVE trial in women with postmenopausal osteoporosis (NCT01343004) using three-dimensional (3D)-processing of dual X-ray absorptiometry (DXA) scans indicated greater increases in total hip cortical volumetric bone mineral density (Ct.vBMD) and estimated indices of hip strength following 18 months of abaloparatide (ABL) versus placebo or ...
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What is the difference between infection and disease?
Disease-causing microbes are often found in the human microbiome. So, when does the presence of pathogenic microbes indicate an infection? And when does the presence of infection explain disease? What is an infection? What is a disease? A disease associated with microbes is the outcome of interaction(s) between a microbe(s) and its host in which the host suffers some sort of damage. ...
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Polysaccharides Function as Backbone for Embryonic Osteogenesis
Osteogenesis, or new bone formation, begins in the early stages of embryonic development and continues postnatally until skeletal maturity is reached in early adulthood. Osteogenesis reoccurs in the event of bone trauma, such as a fracture or surgically created defect. Bone mass can also increase in response to chronic weight bearing from daily use or decrease due to a lack of movement or applied ...
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