drug used Articles
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A comparative study of prescribing and transcribing between the women hospital pharmacy and the ASHP: a benchmark approach
The aim of this case study is to compare the performance of the Pharmacy Department in the Women Hospital of the Hamad Hospital Corporation (HMC) of Qatar, with that of the American Society of Health System Pharmacists (ASHP) national survey in terms of prescribing and transcribing of drugs that was conducted in 2001. The methods used in this case study include observation, secondary data ...
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Quinine 90 MHz - Case Study
Quinine Quinine is a drug used to treat a variety of conditions, most notably malaria. It is listed as one of the WHO’s (World Health Organization’s) “Essential Medicines”. Figure 1 shows the 1H NMR spectrum of a 250 mM Quinine in CDCl3 measured in a single scan taking 10 seconds to ...
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Abalone conservation in the presence of drug use and corruption: implications for its management in South Africa
The illegal exploitation of wild abalone in South Africa has been escalating since 1994, despite increased enforcement, leading to collapse in some sections of its range. South Africa banned all wild abalone fishing in 2008 but controversially reopened the fishery in 2010. This paper formulates a poacher's model, taking into account the realities of the abalone terrain in South Africa - the ...
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California Prop65 list
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
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UCT Clean Screen® DAU Cited in Umbilical Cord Drug Testing
Analysis of umbilical cord samples offers forensic toxicologists a method for evaluating maternal drug intake patterns. These matrices may be an uncommon sample for many laboratories, but for those that are tasked with the challenge, solid phase extraction offers the most efficient methodology for the analysis of said compounds. An estimated 5% of expectant mothers use illicit drugs during ...
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Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
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Innovative technology of engineering magnetic DNA nanoparticles for gene therapy
The present research study is a novel innovation materials technology to engineer magnetic DNA nanoparticles for gene therapy and to enhance the localisation and gene expression of a plasmid DNA via magnetic DNA nanoparticles. Spermine (Sm) was chemically introduced to the hydroxyl groups of dextran, a polysaccharide, to obtain cationised dextran (dextran-Sm). When Fe2+ solution was added to the ...
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Chloroquine diphosphate
Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs). MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and ...
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Antibody Selection for ADC Drugs
Antibodies are the precise guidance components of ADCs. In theory, molecules that bring effector molecules to the surface of tumor cells can play the role of antibody guidance The choice of antibody for ADC drugs depends on the target of the disease. Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only ...
By BOC Sciences
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America`s Painkiller Epidemic and What You Can Do
A new study conducted by the National Safety Council (NSC), along with Indiana’s attorney general has found that 80% of Indiana employers have been impacted by prescription drug misuse and abuse by employees. 80% is a substantial figure, causing some to refer to this trend as a painkiller epidemic. This figure is not unique to Indiana, the NSC notes that the results would likely be ...
By SafetyNow
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Analysisof alendronicacidin pharmaceutical formulations
Alendronic acid or Alendronate Sodium is a bisphosphonate drug that inhibits osteoclast-mediated bone resorption. Biphosphates work by binding to the bone and preventing calcium from being removed by osteoclasts. This drug is used to prevent and treat osteoporosis as well as several other bone diseases. Alendronate Sodium is sold as tablets or solutions, alone or in combination with Vitamin D. ...
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Rare Disease Research: from Diagnostic Development to Small Molecule Drug Development
Rare diseases, also known as orphan diseases, affect a small percentage of the population, making them particularly challenging to diagnose and treat. However, thanks to advancements in medical research and technology, significant progress has been made in the field of rare disease research, from developing accurate diagnostic tools to making effective small-molecule drugs. One of the biggest ...
By Protheragen
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Artemisinin 90 MHz - Case Study
Artemisinin Artemisinin is a widely used drug in the standard treatment of malaria. It is extracted from the plant Artemisia annua, sweet wormwood, but can also be produced in a semi-synthetic fashion. Figure 1 shows the 1H NMR spectrum of a 250 mM Artemisinin sample in CDCl3 measured in a single scan taking 10 seconds to ...
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Assessing FDA's risk methodology at pharmaceutical manufacturing sites
This research analyses the US Food and Drug Administration's (FDA's) risk methodology used for inspecting pharmaceutical manufacturing sites. It reviews the procedures, regulations, and violations specified in FDA warning letters (WLs). In particular it focuses on the time period between 2004-2009, as the FDA transitioned and formalised this new approach to site inspections. One of the principal ...
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UVC helps cut heating costs in jails
If you think it’s hard to get HVAC money for schools and similar public buildings, there is a harder nut to crack: correctional facilities. It can be even more difficult to get additional funds appropriated to improve conditions in buildings where people are incarcerated. Compounding the problem, many correctional facility employees are in close proximity with the inmate community daily. ...
By E-CO
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Symberix Featured in PNAS
Durham, NC (April 28, 2020) - A review article published in PNAS highlights Symberix's efforts to understand the role of the human microbiota in drug efficacy and toxicity. Symberix co-founder Matt Redinbo is featured in the article alongside other leaders from the emerging field of “pharmacomicrobiomics” -- the study of mechanisms behind the microbial impact on drug metabolism. ...
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A Brief Introduction to Functional PEGs
Due to its biological inertness and good biocompatibility, polyethylene glycol (PEG) has a wide range of applications in the pharmaceutical industry, biological materials, cosmetics, and analytical science. A number of compounds, such as proteins, peptides, oligonucleotides, drugs and liposomes, after being modified by PEG covalent bonding, can effectively extend the circulation time in the body, ...
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Implementation of FDA’s new antibiotic rules
On Wednesday, December 11, 2013, the U.S. Food and Drug Administration (FDA) announced two coordinated actions based on its belief “that production use indications such as ‘increased rate of rate of weight gain’ or ‘improved feed efficiency’ are no longer appropriate for the approved conditions for medically important antimicrobial drugs.” First, it released ...
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Getting an insight in the determinants of new product introductions of US biopharmaceutical start-ups
This paper analyses which organisational and industrial factors influence the chance that a US biopharmaceutical start-up is able to introduce a new drug on the US market. Specific attention is paid to the critical mass a biotech company should obtain to improve its chances of bringing a new drug to the market. In the same vein, the economies of scale in R&D are taken into consideration. Second, ...
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Key points to succeed in Artificial Intelligence drug discovery projects
Abstract Drug discovery and development is an expensive, complex, and time-consuming task [5]. Recently, the development of artificial intelligence (AI) approaches to drug discovery, specifically de novo drug design through the use of deep generative models, has triggered a lot of interest in the drug hunter community, especially as an important tool to speed up the process ...
By Iktos
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