Cardiovascular Disease Articles
-
What Is Metabolomics?
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and ...
-
Top Advances in Echocardiography Transforming Cardiac Imaging on World Heart Day
In honor of World Heart Day on September 29, we're diving into the world of cardiovascular diagnostics. Echocardiography, one of the most widely used screening and diagnostic modalities in healthcare, has seen a resurgence thanks to advances and groundbreaking innovations within the last few years. Join us as we explore the top trends shaping these diagnostic methods. 1. ...
-
Unlocking the Possibilities of Customized Ionic Channel Expression Systems
Ionic channels, which are proteins present in the membranes of all living cells, are gaining significant importance in the fields of bio-medicine and biotechnology. They are responsible for the transmission of signals across cell membranes and are instrumental in multiple biological processes. This raises the demand for a systematic mechanism that can control their expression. The customized ...
-
Enzymes Used for Producing Homocysteine Assay Kit: Unlocking the Secrets of Homocysteine Detection
Homocysteine, an important biomarker in the field of clinical diagnostics, plays a significant role in assessing cardiovascular disease risk, vitamin deficiencies, and genetic disorders. Accurate and sensitive detection of homocysteine levels is crucial for early intervention and personalized patient care. In this article, we delve into the fascinating world of enzymes for producing the ...
-
Unravelling the Hypertension Puzzle
In this busy and crowded world, no one has the time or energy to look after themselves; our lack of effort and diminished sense of responsibility towards our health has led to stress, tension, and various health issues becoming an inseparable part of our lifestyle. One of the most popularly spread health issues is hypertension. According to estimates by The World Health ...
-
Will Metformin Be Replaced By SGLT-2 Inhibitors
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
-
G Protein-Coupled Receptors targeted by antibodies raised against three dimensional epitopes
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...
-
Emerging therapy for HFpEF: SGLT2 inhibitors
Recent clinical trials investigating sodium-glucose cotransporter 2 inhibitors (SGLT2i) have highlighted that this drug is highly effective in treating patients with heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease which accounts for more than half of all heart failure (HF) hospital admissions and is an increasing disease burden. [1] The prevalence of HFpEF is ...
-
Huateng Pharma Develops Intermediates of Semaglutide For TD2
According to the latest IDF Diabetes map, the global prevalence of diabetes reached 10.5% in 2021, with 537 million adults living with diabetes. China has become a disaster zone for diabetes, with the largest number of adults with diabetes in the world. In the past 10 years (2011-2021), the number of people with diabetes in China increased from 90 million to 140 million, an increase of 56%. The ...
-
Clinical CRISPR Success Demonstrates Need for Quality Control
The Clinical CRISPR Successes Are Stacking Up. But Where’s the Emphasis on Quality Control? In mid-September, Intellia released some promising data on two of their CRISPR-based therapeutics. These results are a significant milestone for genome editing and validation of its effectiveness in the clinic. However, the safety of CRISPR-based therapeutics has been a major concern and part of a ...
By CRISPR QC
-
Array-based Methylation Detection Explores the Mysteries of Cancer
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene ...
By CD Genomics
-
What Is Single-Cell Sequencing and How to Achieve It?
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent information on the vital activities of numerically dominant cells, while failing to accurately reflect much of the information on cellular heterogeneity ...
By CD Genomics
-
Walk with Tab for Heart Health
Tab Lassiter – an employee of global vaccines leader CSL Seqirus – is about to receive a second transplant in an ongoing battle with a heart condition. He shares his story to explain why it’s critical to spread the word about heart health. Tab Lassiter once spent eight months resting anxiously in a hospital bed with cardiomyopathy, a condition that can lead to heart ...
-
Mitochondrial Proteins
Mitochondria are dynamic organelles with bilayer membranes. Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health ...
-
Dental Problems Linked To Heart Disease and Diabetes
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
-
Efficacy and Detection of Ceramide
Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitute the intercellular lipids (ceramide 50%) involved in maintaining the skin barrier function. It also has various ...
-
The Link Between Smoking and Cognitive Decline
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
-
Development of a Bioartificial Vascular Pancreas
Abstract Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased ...
-
5 Things You Can Do in 2022 for Better Heart Health!
Even if heart health isn’t your top concern in the new year, you can’t go wrong staying on top of your cardiovascular wellbeing. Sadly, heart disease is the leading cause of death in the United States, according to the Centers for Disease Control (CDC). And a recent study found that 40% of adults between the ages of 50 and 64 without a heart-disease diagnosis still had early signs of ...
By BIOLIFE4D
-
In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
By VeriSIM Life
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you