Arch - Model Anti-CD47 - Antibody for Cancer
Anti-CD47 therapies block the CD47/SIRPα interaction, the “don’t eat me” mechanism for macrophages. AO-176 is a humanized anti-CD47 IgG2 monoclonal antibody with a potential best-in-class profile. Beyond blocking, AO-176 has several additional mechanisms of action that make this a highly-differentiated therapy among agents in this class.
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